Genistein, an isoflavone from soy, may stimulate the expression of an
enzyme linked to better blood flow, suggests a new animal study that my
have implications for high blood pressure in humans. «Our data suggest
that genistein has direct genomic effects on the vascular wall that are
unrelated to its known actions, leading to increased eNOS expression and
NO synthesis, thereby improving hypertension,» wrote Hongwei Si and
Dongmin Liu from Virginia Polytechnic Institute and State University.
The researchers report that the isoflavone enhanced the expression of
eNOS by 1.8 to 2.6-fold of control, and the subsequent synthesis of NO
in both HAEC and HUVEC when used in doses between one and 10 micromoles
per litre. These concentrations are «physiologically achievable
concentrations in individuals consuming soy products,» they said. When
the rats were supplemented with genistein, the researchers observed a
restoration of eNOS levels in the aorta, in addition to improvements in
aortic wall thickness. The hypertension of the animals was eased, wrote
Si and Liu. The research adds and expands the science linking
isoflavones to improvements in cardiovascular health. Previously,
studies have reported improvements in blood cholesterol levels, and
easing blood clotting.
Category: Productos
Source: NutraIngredients