The potential heart health benefits of conjugated linoleic acid (CLA)
may be linked to its ability to alter protein expression in platelets,
says a new study that may explain some of the anti-atherogenic effects
of the fatty acids.
Supplementation with CLA (cis-9, trans-11) resulted for three month was associated with alterations in 40 proteins in the platelets of 40 overweight but healthy people participating in a double-blind, randomized, placebo-controlled, paralle-group trial.
«This comprehensive study of platelet proteomics in a dietary trial of a 80:20 cis-9, trans-11 CLA blend revealed many intriguing findings worthy of further investigation,» worte the researchers.
«The focal adhesion pathway appeared an important mechanism of action which could contribute to the previously reported antiatherogenic effects of dietary cis-9, trans-11 CLA.»
CLA is a fatty acid naturally present in ruminant meat and dairy products. Due to changes in the Western diet, average intake of CLA has fallen; if the fat is removed from a dairy product to make a low fat version that will be acceptable to consumers, CLA is removed along with it.
Using proteomic techniques the researchers deduced that CLA supplementation produced «significant alterations in levels of 46 spots of which 40 were identified».