Antioxidant vitamins may protect against female cancer
By Stephen Daniells, 03-Jun-2009
Increased intakes of vitamins C and E and beta-carotene may reduce the risk of cancer of the uterus, according to a new review and meta-analysis of the science to date.
Writing in Cancer Causes and Control, US scientists report that for every 1,000 microgram increase per 1,000 kcal of diet of beta-carotene was associated with a 12 per cent reduction in the risk of endometrial cancer.
Similarly, for every 50 milligram increase per 1,000 kcal of vitamin C the risk of endometrial cancer was reduced by 15 per cent, and for every 5 milligram increase per 1,000 kcal of vitamin E the risk of endometrial cancer was reduced by 9 per cent.
Endometrial cancer is the fifth most common cancer among women worldwide – around 7,000 American women die from the disease annually – but incidence of the cancer varies more than 10-fold worldwide.
The results are based on data from 12 case-control studies, and intakes from supplements were not considered by the researchers, led by Elisa Bandera from the Cancer Institute of New Jersey.
Commenting on the potential mechanism, the US-based researchers noted that antioxidant vitamins may reduce the risk of cancer by limiting oxidative damage to DNA.
Bandera worked in collaboration with scientists from the University of Medicine and Dentistry of New Jersey, the American Cancer Society, and Kaiser Permanente
Source: Cancer Causes and Control
July 2009, Volume 20, Number 5, Pages 699-711doi: 10.1007/s10552-008-9283-x
“Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis”
Authors: E.V. Bandera, D.M. Gifkins, D.F. Moore, M.L. McCullough, L.H. Kushi